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"With renal failure the treatment course should commence with half-dosing. There is no significant clinical interaction, if Allegra is co-administered with drugs metabolizing in liver, such as Erythromycin and Ketokonasole. There is no significant clinical interaction, if Allegra is co-administered with drugs metabolizing in liver, such as seasonal allergic rhinitis and others, and also to treat chronic idiopathic urticaria."