It is recommended to take it at the same times each day to maintain even levels of the medication. Bupropion sustained-release should be taken at the same times each day to maintain even levels of the medication. The capsule, especially with the extend-release variety, can cause adverse reactions. You have to take it at the same times each day to maintain even levels of the medication. Generic Wellbutrin is usually taken one to three times a day and may be taken with or without food. For the actual stress of quitting.
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