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With minimal effect on many of the other chemicals in the brain that helps maintain mental balance. Do have problems note that they are much less severe than they were on older anti-depressants. The safety and efficacy of initiating treatment with Lexapro to begin with. Lexapro is an astonishing antidepressant medication that can help many types of depression and helps depressed individuals live the kind of life that non-depressed people take for granted. Lexapro works by increasing the amount of serotonin, a substance in the brain, is an important factor in the development and severity of depressive symptoms, such as sad mood, fatigue, lack of pleasure, etc. Escitalopram appears to relieve depression by increasing serotonin levels with minimal effect on many of the other chemicals in the brain that helps maintain mental balance.