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Premarin is also controversial because the health risks to women of absorbing a substance made from equine waste may not be fully known. Conjugated estrogens are sometimes used as part of cancer treatment in women and men. Conjugated estrogens? Premarin is also controversial because the health risks to women of absorbing a substance made from equine waste may not be fully known. It is important to take conjugated estrogens regularly to get the most benefit. Long-term treatment with conjugated estrogens may increase your risk of developing these conditions.
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