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Care should be taken if adrenaline is given with Propranolol, as this combination can cause severely high blood pressure and heart failure. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and the velocity and extent of myocardial contraction. Propranolol is used to prevent migraine, although it is not fully understood how Propranolol works in this area. Propranolol should be administered with caution since it may block bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta-adrenergic receptors.