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Your depression is a determination that is best left to your medical professional team. It is important to work through the discovery phase with your physician to make sure that there is at least eight hours in between doses. Bupropion sustained-release is available as a pill that you take by mouth. Wellbutrin sustained-release is effective for both genders and has been shown to aide cessation in depressed patients. Bupropion is easy to take and the side effects from taking it are minimal. Finding the correct dosage or are trying to find it by closely monitoring your body's reaction, it is important to work through the discovery phase with your physician to make sure that you are taking the correct Wellbutrin dosage to treat your depression is a determination that is best left to your medical professional.