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If you take it more than 24 hours after the start of signs or symptoms. Valaciclovir is most effective if it is started within 48 hours of when the rash first appears. Once-daily Valtrex is also the only medication proven to reduce the risk of spreading genital herpes. It is not known if Valtrex prevents the spread of the herpes virus. It is not known if Valtrex prevents the spread of the herpes virus. Once daily, whether or not you have symptoms, can reduce the number of outbreaks experienced in a year's time.
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