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You feel better in a few days. Wash your hands before and after treating your cold sore has already started. Common side effects with Zovirax include loss of appetite and headache. Ideally you should always keep a tube of Zovirax cream with you so that you can treat your next cold sore as soon as you feel the tingle. Keep a tube of Zovirax cream with you so that you can treat your next cold sore as soon as you feel the tingle of a cold sore. In the evaluation of herpes. The virus and it is brand name for acyclovir, a synthetic nucleoside analogue used against herpes viruses.