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Zithromax should be taken on an empty stomach two hours after a meal since food reduces its absorption. Your doctor if you experience any new side effects while taking a course of Azithromycin. Zithromax is used to treat bacterial infections. Clinical trials have shown that Azithromycin ought to be taken at least one hour pending to or two hours following meals. Zithromax should be taken on an empty stomach two hours after a meal since food reduces its absorption. Zithromax is an unusual antibiotic in that it stays in the body for a significant period of time after the required doses.